However, sufferers were returned to standard care after six months and the effect was not sustainable on the 12-month mark. Occasionally there could also be crescents and signs of necrosis and the glomeruli could also be lobulated and resemble membranoproliferative glomerulonephritis (1). Many of the studies had the 17 treatment of symptomatic patients stepped down during the run-in phase, which would have had an impact on the results as patients in the control group may have been undertreated 3m antimicrobial sponge
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