This capacity to adjust is primarily dependent on variations in heart fee, which at relaxation is most often between 50 and 70 beats per minute and as much as 170–200 per minute at maximal exertion. The most frequent causes of the main practical valvular lesions are as follows: • Aortic stenosis: calcification of anatomically regular and congenitally bicuspid aortic valves • Aortic insufficiency: dilation of the ascending aorta, related to hypertension and getting older. Central coagulative necrosis is surrounded by anaerobic micro organism, Actinomycetes israelii
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