If the stone obstructs the ureteropelvic junction, pain localizes to the flank; because the stone strikes down the ureter, pain moves downward and anterior. Even right now, one can hear sturdy claims for success, yet it is uncommon that public demonstrations are given. Since a disease modifying effect correlated with a persistent delay within the underlying neuropathological course of is tough to show with out adequately validated and certified biomarkers as end result parameters, a slowing or delay of scientific decline as demonstrated by revolutionary trial designs may be acceptable as an alternative development aim (see part eight
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