A identified or suspected chromosome or genome abnormality in a firstdegree relative is a sign for chromosome and genome evaluation. Sometimes we may get a clue from the assertion of a symptom that will recommend a sure remedy, and we must be very cautious to not enable this to prejudice us in favor of the treatment advised by questioning the patient along this line, and thus perhaps bias the patient in his replies. These include necropsy of infected animals, harvesting of tissues or fluids from infected animals or eggs, or intranasal inoculation of animals
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